Supramolecular Polyphenol?DNA Microparticles for In Vivo Adjuvant and Antigen Co?Delivery and Immune Stimulation

DNA-based materials have attracted interest due to the tunable structure and encoded biological functionality of nucleic acids. A simple general approach synthesize with fine control over morphology bioactivity is important expand their applications. Here, we report synthesis particles via supramolecular assembly tannic acid (TA) DNA. Uniform different morphologies are obtained using a variety DNA building blocks. The enable co-delivery cytosine-guanine adjuvant sequences antigen ovalbumin in model cells. Intramuscular injection mice induces antigen-specific antibody production T cell responses no apparent toxicity. Protein expression cells shown capsules assembled from TA plasmid This work highlights potential as universal material for directing into gene vaccine delivery platforms.